SesaMAX™ contains sesamin, one of the most abundant lignans in sesame seeds. Sesamin has been shown to decrease fatty acid formation and increase hepatic fatty acid oxidation (fat burning). Sesamin can also support healthy HDL (good cholesterol) levels and maintain healthy LDL (bad cholesterol) levels. SesaMAX™ is further enhanced with Flax Seed Oil, containing a rich source of EFA's like Omega-3 and Alpha Linolenic Acid (ALA). Flax Seed Oil has been documented to support potent fat reducing and health promoting properties.

SesaMAX™ Lipo Incinerating Complex™

by Chris Atkinson, 2005

SesaMAX™ is a break through fat loss formula comprised of Sesamin and Flax Seed Oil. SesaMAX™ is a unique compound that works in two ways to help you get lean and to keep you lean. SesaMAX™ increases fat oxidation (burning) and decreases fat storage. Sesamin can also help you diet better by fueling ketosis when you cut carbs. The added benefit of flax seed oil in SesaMAX™ provides a rich source of essential fatty acids and "good" fat. Flax seed oil can be very beneficial for fat loss and will provide your body with all the essential fatty acids it needs during dieting. Essential fatty acids have been shown to support healthy metabolic function, reduce oxidative stress, and maintain healthy cholesterol. SesaMAX is a dieting breakthrough and can help you turn into a fat burning machine.

What is Sesamin
Sesamin is a lignan that is found in sesame seeds. A lignan is a molecule that combines with a receptor to activate that receptor, and create a response. The receptor and lignan will then perform a function in the body. Sesamin is a lignan for the Peroxisome Proliferator-ActivatorReceptor Alpha (PPARalpha). The receptor is found in muscle, liver, and heart tissue and is involved in the oxidation (burning) of fat. Activation of PPARalpha increases gene expression of the fatty acid oxidation (burning) enzymes and decreases gene expression of lipogenic (fat storing) enzymes. Sesamin has been shown to be a potent PPARalpha activator. The majority of fat oxidation occurs in skeletal muscle cells and the liver. PPARalpha activation by sesamin increases fat oxidation by increasing the expression of enzymes involved in the oxidation of fatty acids. SesaMAX™ can increase some types of enzymes that help shuttle fatty acids into the mitochondria of cells, where they are burned.

Decreased fat storage
SesaMAX™ is an amazing fat burning supplement for several reasons. First, Sesamin has been shown to decrease the lipogenic (fat storing) gene expression of several different enzymes involved storing fat. These enzymes include sterol regulatory element binding protein-1 (SREBP-1), acetyl-CoA carboxylase, and fatty acid synthase. Decreasing these lipogenic enzymes means that less fat is esterifized in the liver and less fat is stored in the body. Second, flax seed oil provides the essential fatty acids necessary to support optimal metabolism in the body. Supplementing with essential fatty acids can actually help your body loose fat, maintain healthy cholesterol and reduce oxidative stress.

Ketosis
Ketogenesis occurs when fatty acid oxidation is increased to a point where the liver cannot metabolize the fatty acids completely. Excess acetyl-CoA (which can be created from glucose, fat or amino acid metabolism) is converted to ketones in the liver and released into the bloodstream for use by other tissues as fuel (specifically the brain). Ketones are very important during a low carb diet, because the brain cannot use fatty acids for fuel. The brain can use glucose, but when glucose is low, the brain will turn to ketones for its energy. Sesamin has been shown to increase ketone production. Increasing ketone production with Sesamin should have protein-sparing effect, because less amino acids will be needed to create ketones. The addition of flax seed oil to SesaMAX will also support ketogenesis and help you keep as much muscle as possible while dieting. This means your muscle mass will be spared while dieting and you will loose more fat!

Other Benefits
SesaMAX™ has other benefits in addition to promoting fat loss. Both Sesamin and flax seed oil have been shown to act as antioxidants and provide liver function support. SesaMAX™ can help you maintain healthy cholesterol levels, while supporting high density lipoprotein (HDL aka "good cholesterol") levels.

REFRENCES:

1. Akimoto K., et al. 1993. Protective effects of sesamin against liver damage...in rodents. Ann Nutr Metab. ;37(4):218-24.
2. Ashakumary L., et al. 1999. Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. Oct;48(10):1303-13.
3. Fukuda N, et al. 1999. Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver. J Nutr Sci Vitaminol (Tokyo). Aug;45(4):437-48
4. Hirose N., et al. 1991. Inhibition of...absorption and synthesis in rats by sesamin. J. Lipid Res. Vol 32, 629-638.
5. Ide T., et al. 2001. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. Nov 30;1534(1):1-13.
6. Ide T., et al. 2003. Sesamin, a Sesame Lignan, as a Potent Lipid-Lowering Food Component. JARQ 37 (3), 151 - 158.
7. Ide T. 2004. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochim Biophys Acta. Jun 1;1682(1-3):80-91.